BIOPHARMACEUTICAL TECHNOLOGY

BIOPHARMACEUTICAL TECHNOLOGY Question Papers (Supple, Nov, 2008)

SET: 1

1. Describe the development of drug and pharmaceutical industries in India.

2. (a) Why are drugs referred to as xenobiotics? Explain. (b) What are soft drugs? Why are they considered safe (w.r.t the metabolites formed) and have short half life.

3. (a) What is meant by pharmacokinetics? What is its significance. (b) Give examples of zero-order rate processes.

4. What are the different types of reactions involved in the case of bulk drug manufacturing.

5. Write about different stages involved in sugar coating.

6. Write about different additives used for the development of parentals dosage forms.

7. Answer any three of the following:
(a) stimulant laxatives.
(b) hyperosmotic laxatives
(c) bulk forming laxatives
(d) Lubricant laxatives.

8. What are synthetic or non-steroidal esterogens? Describe about their importance and side effects?

SET: 2

1. What are antimalarial drugs? Give structure and uses of the following:
(a) quinine
(b) Trimethoprin
(c) Chloroquine
(d) Amodiaquine

2. Which physiochemical properties of the drug limit its distribution, describe in detail?

3. Why pharmacokinetic models are most important in the case of drug metabolism, explain in detail?

4. (a) Describe the laboratory filtration equipment and their usage? (b) What is cake filtration? Describe the cake filtration process in the bulk drug manufacturing industry.

5. Write about different stages involved in sugar coating?

6. Write about the different evaluation procedures for parental dosage forms.

7. Write the synthesis properties and used of ascorbic acid.

8. Write an account of different types of penicillins and write the structures, properties and uses of benzyl penicillin and phenoxymethyl penicillin.

SET: 3

1. (a) Describe the patents and designs act? Describe in brief the procedure for obtaining a patent? (b) what is meant by "piracy of registered design" and reciprocal arrangements under designs act? Define the term 'Patent' and 'invention'.

2. What are the characteristics of specialized transport systems? How can the kinetics of such processes may be described?

3. Why pharmacokinetics models are more important in the case of drug metabolism, explain in detail?

4. (a) How the pH is controlled in the manufacture of bulk drugs? Explain with examples.
(b) How the temperature is controlled in the case of bulk drug manufacturing, explain with examples.

5. (a) Write the advantages and disadvantages of the tablet dosage form. (b) Write about the manufacture of the tablets by direct compression.

6. Write about different glass containers used for the packing of dosage forms.

7. Write the synthesis properties and uses of ascorbic acid.

8. Write the types of non-steroidal oral contraceptives for women. Describe about their adverse effects, efficiency and failures.

SET: 4

1. (a) Describe the preventio of food Adulteration Act and Rules. (b) Answer any two of the following:
(i) central food on labratory
(ii) standards of quality
(iii) preservative in food artivle
(iv) coloring matter in food articles.

2. List the factors influencing protein binding of drugs?

3. (a) Define pharmacokinetics. Name and define the three pharmacokinetic parameters that describe a typical plasma level-time curve. (b) What are the various pharmacodynamic parameters?

4. (a) Write differences between batch mixing and continuous mixing. (b) What is the condensation reaction? How these reactions are useful in the bulk drug manufacturing process, explain with example.

5. Write about different stages involved in sugar coating.

6. Write about different glass containers used for the packing of dosage forms.

7. What are the water-soluble vitamins? Explain their properties and uses by taking some examples?

8. What are antibiotics? Discuss their chemical and mechanism based classification?
comments (0) Permalink
LABELS: BIOPHARMACEUTICAL TECHNOLOGY
BIO PHARMACEUTICAL TECHNOLOGY (2006,Reg)
POSTED BY M.S.CHOWDARY AT 12:24 PM
Monday, November 24, 2008
SET :1

How many types of licenses can be issued for the manufacture of drugs? Describe the general procedure for obtaining a license stating the conductions to be satisfied.
How are ionic/ionizable drugs absorbed
Buffered aspirin tablets are more suitable than sodium salt form of aspirin. Why?

3. Define pharmacokinetics. Name and define the three pharmacokinetic parameters that describe a typical plasma level time curve
What are the various pharmacodynamic parameters?

What are the parameters used in the manufacture of bulk drugs? How the parameters are controlled?
Write the operation of rotary tablet press.
What is quality assurance and how does it control the quality of drug product?
a) Differentiate between fat soluble vitamins and water soluble vitamins. Give examples, write their structure, properties and uses.
What are antibiotics? Discuss their chemical and mechanism based classification.

SET :2

1. Define the term “ antidepressant “. Briefly describe the chemical classification of antidepressants.
Write structures and uses of the following drugs.
a) Penicillin
b) Phenelzine sulfate (Nordil)
c) Antiriptyline hydro chloride (Enovil)
2. Which physiochemical properties of the drug limit its distribution, describe in detail?
3. What are the various diagnostic applications of radioisotopes?
4. Write the flow diagram of reactors in the bulk drug industries by using any example of bulk manufacturing process and explain.
How the pH and temperature effect the bulk drug manufacturing process. Explain with examples.
5. Write about the different formulation procedures available for the sustained action dosage forms.
6. Write about different excipients used in the manufacture of parenteral dosage forms.
7. Write the synthesis properties and uses of ascorbic acid.
8. a) What are hormones? How they are useful in our body? b) What are adrenal cortex hormones? Write the structure, properties and uses of cortisone acetate

SET :3

How many types of licenses can be issued for the manufacture of drugs? Describe the general procedure for obtaining a license stating the conductions to be satisfied.
2. Why drugs reffered to as xenobiotics? Explain.
What are soft drugs? Why are they considered safe (w.r.t. the metabolites formed) and have short life.
3. Describe about the biological effects of radiations.
4. Write short notes on :
a) Wet and dry milling
b) Classification of solids based on drying behavior
c) Pan dryers
5. Write the operation of rotary tablet press.
6. Write about the different evaluation procedures for parenteral dosage forms.
7. Differentiate between stimulant laxatives and hyperosmotic laxatives with suitable examples.

8. Why some of the sulpha drugs are called as antibiotics? Describe the structure of tetracyclines.


SET :4

1. What types and classes of advertisements are exempted under the drugs and magic remedies act and rule? Who is empowered to grant such exemptions? What classes of advertisements are prohibited to be exported or imported? Define the terms “advertisement” and “magic remedies” .
2. Discuss briefly the factors affecting GE (gastic emptying) of drugs?
Quote examples of complexation used to enhance bio – availability of a drug?
3. Define pharmacokinetics. Name and define the three pharmacokinetic parameters that describe a typical plasma level time curve
What are the various pharmacodynamic parameters?
4. What is the importance of the flow sheet in the bulk drug manufacturing? Describe about different types of general reactions involved in the bulk drug production.
5. Write the operation of rotary tablet press.

What is quality assurance and how does it control the quality of drug product?
7. What are fat soluble vitamins? Explain their properties and uses by taking some examples.
8. a) Write about male sex hormones and oral contraceptives or pills. b) Write about corpus luteum hormones or gestogens